891831-22-4

Basic information

• Product Name: Carbamic acid, [(1S,5R,6R)-6-(acetylamino)-3-cyano-5-(1-ethylpropoxy)-3-cyclohexen- 1-yl]-, 1,1-dimethylethyl ester
• CAS NO: 891831-22-4
• Molecular Formula: C19H31N3O4
• Molecular Weight: 365.473
• Mol File: 891831-22-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S,5R,6R)-6-(acetylamino)-3-cyano-5-(1-ethylpropoxy)-3-cyclohexen- 1-yl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,5R,6R)-6-(acetylamino)-3-cyano-5-(1-ethylpropoxy)-3-cyclohexen- 1-yl]-, 1,1-dimethylethyl ester(891831-22-4)
• EPA Substance Registry System: Carbamic acid, [(1S,5R,6R)-6-(acetylamino)-3-cyano-5-(1-ethylpropoxy)-3-cyclohexen- 1-yl]-, 1,1-dimethylethyl ester(891831-22-4)

Safety Data

• Hazardous Substances Data: 891831-22-4(Hazardous Substances Data)

Upstream product

• 891831-21-3 (3R,4R,5S)-4-amino-5-(tert-butoxycarbonylamino)-1-cyano-3-(1-ethylpropoxy)cyclohexene 
• 108-24-7 acetic anhydride 
• 891831-16-6 (4R,5S)-4,5-bis(tert-butoxycarbonylamino)cyclohexen-3-one 
• 891831-18-8 (6-tert-butoxycarbonylamino-4-cyano-2-oxo-cyclohex-3-enyl)-carbamic acid tert-butyl ester 
• 891831-20-2 (3R,4R,5S)-4,5-bis(tert-butoxycarbonylamino)-1-cyano-3-(1-ethylpropoxy)cyclohexene 
• 891831-19-9 (3S,4R,5S)-5-(tert-butoxycarbonylamino)-3,4-(tert-butoxycarbonylimino)-1-cyanocyclohexene 
• 930275-47-1 (6-acetylamino-3-cyano-5-oxo-cyclohex-3-enyl)-carbamic acid tert-butyl ester 
• 930275-48-2 (1S,2R)-2-(acetylamino)-1-(tert-butoxycarbonylamino)-4-cyclohexen-3-one 
• 927395-71-9 tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-hydroxycyclohex-3-en-1-yl]carbamate 
• 584-02-1 2-pentanol 
• 927395-72-0 tert-butyl [(1R,2S,6S)-7-acetyl-4-cyano-7-azabicyclo[4.1.0]hept-4-en-2-yl]carbamate 

Downstream Products

• 196618-13-0 oseltamivir 
• 204255-11-8 oseltamivir phosphate 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF INTERMEDIATE FOR THE PREPARATION OF OSELTAMIVIR PHOSPHATE

The present invention discloses an economic, simple, azide and azindine complexity free process for the synthesis of osletamivir phosphate (Tamiflu) by stereospecific amidoalkylation of imidazothiazolone from easily available L-cysteine via Ramberg- Backlund reaction and Sharpless-Reich protocol.

Second generation catalytic asymmetric synthesis of tamiflu: Allylic substitution route

(Chemical Equation Presented) Catalytic asymmetric synthesis of Tamiflu, an important antiinfluenza drug, was achieved. After the catalytic enantioselective desymmetrization of meso-aziridine 3 with TMSN3, using a Y catalyst (1 mol %) derived from ligand 2, an allylic oxygen function and C1 unit on the C=C double bond were introduced through cyanophosphorylation of enone and allylic substitution with an oxygen nucleophile. This second generation route of Tamiflu is more practical than our previously reported route.