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7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE, also known as MPI-0479605, is a chemical compound belonging to the imidazo[1,2-a]pyridine family. It functions as a kinase inhibitor, specifically targeting the ERK5 protein, which plays a crucial role in cell growth and proliferation regulation. By inhibiting ERK5, 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE has the potential to impede cancer cell growth and is under investigation for its anti-cancer properties. Furthermore, it may have applications in treating inflammatory and cardiovascular diseases due to the involvement of the ERK5 pathway in these physiological processes. The unique structure and mechanism of action of 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE make it a promising candidate for drug development and research.

89185-45-5

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89185-45-5 Usage

Uses

Used in Pharmaceutical Industry:
7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE is used as a kinase inhibitor for targeting the ERK5 protein, which is involved in cell growth and proliferation. Its application is primarily for the development of anti-cancer therapies, as it has the potential to disrupt the growth of cancer cells.
Used in Oncology:
7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE is used as a potential anti-cancer agent, being studied for its ability to inhibit the ERK5 protein and, consequently, impede the growth of cancer cells.
Used in Treatment of Inflammatory Diseases:
7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE is used as a potential therapeutic agent for inflammatory diseases, given the involvement of the ERK5 pathway in these conditions.
Used in Cardiovascular Disease Treatment:
7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE is used as a potential treatment for cardiovascular diseases, as the ERK5 pathway also plays a role in these physiological processes.

Check Digit Verification of cas no

The CAS Registry Mumber 89185-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,1,8 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 89185-45:
(7*8)+(6*9)+(5*1)+(4*8)+(3*5)+(2*4)+(1*5)=175
175 % 10 = 5
So 89185-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H13N3/c1-10-7-8-17-12(9-10)16-13(14(17)15)11-5-3-2-4-6-11/h2-9H,15H2,1H3

89185-45-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Methyl-2-phenylimidazo[1,2-a]pyridin-3-amine

1.2 Other means of identification

Product number -
Other names Imidazo[1,2-a]pyridin-3-amine,7-methyl-2-phenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89185-45-5 SDS

89185-45-5Downstream Products

89185-45-5Relevant academic research and scientific papers

Photoinduced, Direct C(sp2)?H Bond Azo Coupling of Imidazoheteroarenes and Imidazoanilines with Aryl Diazonium Salts Catalyzed by Eosin Y

Saba, Sumbal,Dos Santos, Caio R.,Zavarise, Bruno R.,Naujorks, Aline A. S.,Franco, Marcelo S.,Schneider, Alex R.,Scheide, Marcos R.,Affeldt, Ricardo F.,Rafique, Jamal,Braga, Antonio L.

, p. 4461 - 4466 (2020/02/25)

Herein, a greener approach to the eosin Y-Na2 catalyzed, C(sp2)?H bond azo coupling of imidazoheteroarene with aryl diazonium salts is described, under acid free conditions. This direct photoredox process resulted in the corresponding azo products in good to excellent yields. Besides, this new approach could also be applicable to anilines, which is a poorly reactive substrate by other methods. The main features of this reaction are that it provides high yields and is gram-scalable and applicable to biologically relevant imidazoheteroarenes and -anilines.

Cyclisation Reactions of some 3-Nitrosoimidazo-pyridines and -pyrimidines. Ring-opening/Ring-closure Reactions with Triethyl Phosphite: Reassignment by X-Ray Crystal Structure and Nuclear Magnetic Resonance

Teulade, Jean C.,Escale, Roger,Viols, Henry,Chapat, Jean P.,Grassy, Gerard,et al.

, p. 2663 - 2667 (2007/10/02)

Deoxygenation of 3-nitroso-2-phenylimidazo-pyridines and -pyrimidines with triethyl phosphite does not lead to the products described in the literature as pyrido- and pyrimido-imidazoindoles (3) and (4), but to the open-chain derivatives, N-(2-pyri

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