89197-00-2 Usage
Uses
Used in Pharmaceutical Industry:
Efaroxan Hydrochloride is used as a potent α2-adrenergic receptor antagonist for various applications in the pharmaceutical industry. Its selectivity and ability to modulate insulin release make it a valuable compound for research and development of new drugs targeting the α2-adrenergic receptor system and related metabolic pathways.
Biological Activity
Potent, highly selective α 2 adrenoceptor antagonist and imidazoline I 1 receptor ligand (pK i values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A , α 2B , α 2C , I 1 , and I 2 receptors respectively). Promotes insulin secretion, at a site distinct from I 1 or I 2 (the putative I 3 receptor) in vitro and in vivo .
References
1) Chapleo et al. (1984), alpha-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on alpha-adrenoceptor activity; J.Med.Chem., 27 570
2) Eglen et al. (1998), ‘Seeing through a glass darkly’: casting light on imidazoline ‘I’ sites; Trends Pharmacol. Sci., 19 381
3) Olmos et al. (1994), Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors; Eur. .J. Pharmacol., 262 41
4) Berridge et al. (1992), Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats; Eur. J. Pharmacol., 213 205
Check Digit Verification of cas no
The CAS Registry Mumber 89197-00-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,1,9 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 89197-00:
(7*8)+(6*9)+(5*1)+(4*9)+(3*7)+(2*0)+(1*0)=172
172 % 10 = 2
So 89197-00-2 is a valid CAS Registry Number.
