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CAS

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892113-81-4

(3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 892113-81-4 Structure

  • Basic information

    1. Product Name: (3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one
    2. Synonyms: (3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one
    3. CAS NO:892113-81-4
    4. Molecular Formula:
    5. Molecular Weight: 511.464
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 892113-81-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one(892113-81-4)
    11. EPA Substance Registry System: (3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one(892113-81-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 892113-81-4(Hazardous Substances Data)

892113-81-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 892113-81-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,2,1,1 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 892113-81:
(8*8)+(7*9)+(6*2)+(5*1)+(4*1)+(3*3)+(2*8)+(1*1)=174
174 % 10 = 4
So 892113-81-4 is a valid CAS Registry Number.

892113-81-4Relevant articles and documents

(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Biftu, Tesfaye,Feng, Dennis,Qian, Xiaoxia,Liang, Gui-Bai,Kieczykowski, Gerard,Eiermann, George,He, Huaibing,Leiting, Barbara,Lyons, Kathy,Petrov, Aleksandr,Sinha-Roy, Ranabir,Zhang, Bei,Scapin, Giovanna,Patel, Sangita,Gao, Ying-Duo,Singh, Suresh,Wu, Joseph,Zhang, Xiaoping,Thornberry, Nancy A.,Weber, Ann E.

, p. 49 - 52 (2007)

Replacement of the triazolopiperazine ring of sitagliptin (DPP-4 IC50 = 18 nM) with 3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one gave dipeptidyl peptidase IV (DPP-4) inhibitor 1 which is potent (DPP-4 IC50 = 2.6 nM), selective, and ef

PROCESS TO CHIRAL BETA AMINO ACID DERIVATIVES BY ASYMMETRIC HYDROGENATION

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Page/Page column 23; 24, (2010/11/08)

The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand with in situ protection of the primary amine product. The invention also relates to a novel process for the preparation of chiral beta-amino acid amides as inhibitors of the dipeptidyl peptidase-IV of structural formula III and the useful intermediates obtained therein. The products resulting from the instant process are inhibitors of dipeptidyl peptidase-IV and thereby useful for the treatment of Type 2 diabetes.

TARTARIC ACID SALTS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR

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Page/Page column 12-13, (2008/06/13)

Tartaric acid salts of (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl) butanoyl]hexahydro-3-(2,2,2-trifluoroethyl)-2H-1,4-diazepin-2-one are potent inhibitors of dipeptidyl peptidase-IV and are useful for the prevention and/or treatment of non-insulin depe

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