892123-76-1Relevant academic research and scientific papers
Preparation of 2,4-disubstituted cyclopentenones by enantioselective iridium-catalyzed allylic alkylation: Synthesis of 2′-methylcarbovir and TEI-9826
Duebon, Pierre,Schelwies, Mathias,Helmchen, Guenter
experimental part, p. 6722 - 6733 (2009/09/05)
A broadly applicable synthesis of chiral 2- or 2,4-substituted cyclopent-2-enones has been developed by combining asymmetric iridium-catalyzed allylic alkylation reactions and ruthenium-catalyzed ring-closing meta-thesis. Enantiomeric excesses (ee values)
Enantioselective modular synthesis of 2,4-disubstituted cyclopentenones by iridium-catalyzed allylic alkylation
Schelwies, Mathias,Duebon, Pierre,Helmchen, Guenter
, p. 2466 - 2469 (2007/10/03)
Classy combo: Together, the asymmetric indium-catalyzed allylic alkylation and ruthenium-catalyzed ring-closing metathesis lead to an efficient synthesis of chiral cyclopentenones (see scheme). One example is the synthesis of the antitumor agent TEI-9826
