892145-08-3Relevant academic research and scientific papers
Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors
Ducray, Richard,Ballard, Peter,Barlaam, Bernard C.,Hickinson, Mark D.,Kettle, Jason G.,Ogilvie, Donald J.,Trigwell, Catherine B.
, p. 959 - 962 (2008/09/18)
Novel 4-anilino-1H-pyrazolo[3,4-d]pyrimidines have been synthesized and evaluated in vitro for erbB2 and EGFR kinase inhibition. A representative compound displaying oral bioavailability in rat and dog illustrates the potential of this series to provide o
