89226-27-7

Usage

Appearance

White crystalline solid

Solubility

Soluble in water and ethanol

Specific content

Thioacetamide is used as a source of sulfide ions in the synthesis of inorganic and organometallic compounds.
It is used in the pharmaceutical industry as a reagent for the synthesis of various drugs and as a treatment for liver damage in experimental animal models.
Thioacetamide is a common reagent in organic chemistry, used as a precursor for the synthesis of heterocyclic compounds and other valuable chemical products.
It is known for its toxic effects on the liver and used in research as a model compound for studying liver diseases.

InChI:InChI=1/C2H6N2S/c3-1-2(4)5/h1,3H2,(H2,4,5)

Upstream product

• 89226-13-1 2-(N-t-butoxycarbonylamino)thioacetamide 

Downstream Products

• 90374-41-7 (+)-N-(tert-Butoxycarbonyl)-L-phenylalanyl-glycin-thioamid 

Relevant academic research and scientific papers

Preparation of α-aminothioamides from aldehydes

The conversion of aldehydes into α-aminonitriles and thence into imidazolidin-4-thiones has been studied.Hydrolysis of the appropriate imidazolidin-4-thiones gave thioamides of nine naturally occuring α-amino acids.The possible pre-biotic significance of these compounds is discussed.

130. Poly(dipeptamidinium) Salts: Definition and Methods of Preparation

Poly(dipeptamidines) are polypeptide derivatives in which the carbonyl oxygen of each second backbone amide group is replaced by an imine nitrogen (see A).So far, such derivatives have been unknown.Polyprotonated salts of them (= poly(dipeptamidinium) salts) are of interest in view of their intrinsic constitutional relationship to the structure of polynucleotides: the number of covalent bonds between neighboring centers of positive charge in poly(dipeptamidinum) salts is identical to the number of covalent bonds between neighboring centers of negative charge in natural polynucleotides (see D).Poly(dipeptamidinium) polycations and polynucleotide polyanions are constitutionally and electrostatically complementary structures.Since poly(dipeptamidines) are (formally) polymers of dipeptide nitriles, and, since they can be expected to give polypeptides on hydrolysis, the relationship mentioned above deserves attention and experimental study in context with the problem of designing chemical models of biogenesis.This paper describes methods for the chemical preparation, the spectral characterization, and some chemical properties of homodipeptidic poly(dipeptamidinium) salts in the L-alanyl-glycyl and L-phenylalanyl-glycyl series.The methods of preparation include a stepwise construction of defined lower oligomers (up to hexamer) as weel as, in the L-alanyl-glycyl series, a one-preparation poly-condensation procedure leading to polymers containing an average of ca. 20 dipeptamidinium units (Schemes 4,6 and 7).