89227-95-2

Usage

Dihydropyridine derivative

A type of chemical compound belonging to the pyridine family, which is a group of organic compounds that include a six-membered ring with alternating single and double bonds.

Pharmaceutical industry use

Calcium channel blocker 1-tert-butyl 2-methyl 2,3-dihydropyridine-1,2(6H)-dicarboxylate is commonly used in the pharmaceutical industry to treat various cardiovascular conditions by blocking the entry of calcium ions into muscle cells.

Potential applications

Hypertension, angina, and certain types of arrhythmias The compound has been studied for its potential use in treating these conditions by improving blood flow and reducing the workload on the heart.

Mechanism of action

Blocking calcium ion entry into smooth muscle and cardiac muscle cells The compound works by preventing calcium ions from entering these cells, leading to relaxation of blood vessels and decreased cardiac muscle contractility.

Antioxidant and neuroprotective properties

Additional potential benefits The compound has also been investigated for its possible antioxidant and neuroprotective effects, which could provide further therapeutic applications.

Upstream product

• 31139-02-3 (1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid 
• 115-11-7 isobutene 
• 31139-02-3 (1S,2R)-2-(methoxycarbonyl)cyclohex-4-ene-1-carboxylic acid 
• 93603-11-3 1-methyl hydrogen 1,2-cis-1,2-cyclohex-4-ene dicarboxylate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 4841-84-3 dimethyl cis-1,2,3,6-tetrahydrophthalate 

Downstream Products

• 111860-30-1 (1R,2S,5S)-5-Methanesulfonyloxy-2-(methoxycarbonyl-methyl-amino)-cyclohex-3-enecarboxylic acid methyl ester 
• 111515-78-7 methyl (1R,2S,5S)-5-hydroxy-2-cyclohex-3-enecarboxylate 
• 124287-84-9 (1R,6S)-6-<(methoxycarbonyl)amino>cyclohex-3-enecarboxylic acid 
• 811440-28-5 ((1R,2S,5R)-2-Isopropenyl-6-methylene-bicyclo[3.2.1]oct-1-yl)-methanol 
• 811811-12-8 (1R,5R,8R)-4,4-Dimethyl-9-methylene-3-oxa-tricyclo[6.2.1.0^1,5]undecan-2-one 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS

The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition

A serendipitous discovery that the metalloprotease binding profile of a novel class of 2-carboxamide-3-hydroxamic acid piperidines could be significantly attenuated by the modification of the unexplored P1 substituent enabled the design and synthesis of a

Synthesis of optically active methyl 7 β-hydroxykaurenoate with potent neuroprotective activity

(-)-Methyl 7β-hydroxykaurenoate (3) and its 4-demethyl acetate (-)-4 were both synthesized via methods that contained radical cyclization and intramolecular Diels-Alder reactions as key steps. Both compounds displayed potent neuroprotective activity again

An Enantioselective Synthesis of (-)-Fortamine

The aminocyclitol moiety of fortimicin A, (-)-fortamine, was synthesized in an enantioselective manner starting from the chiral half ester, easily available by the enantioselective hydrolysis of a symmetrical diester with pig liver esterase.The present ap

AN EFFICIENT SYNTHESIS OF A KEY INTERMEDIATE FOR OPTICALLY ACTIVE 5,6-CIS-CARBAPENEM ANTIBIOTICS

A versatile intermediate (18) for optically active 5,6-cis-carbapenem antibiotics was synthesized with a highly regioselective intramolecular aldol condensation as a key step.

CREATION OF NOVEL CHIRAL SYNTHONS WITH ENZYMES AND APPLICATIONS TO NATURAL PRODUCT SYNTHESIS. 15. EFFICIENT INTRODUCTION OF CHIRAL CENTERS INTO CYCLOHEXANE RING.

The chiral half-ester 2 obtained by asymmetric hydrolysis of the symmetric diester 1 with pig liver esterase has been shown to be a versatile synthon for various chiral cyclohexane derivatives.