89229-91-4Relevant academic research and scientific papers
A Simple and Broadly Applicable C?N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents
Ma, Xiaofeng,Farndon, Joshua J.,Young, Tom A.,Fey, Natalie,Bower, John F.
supporting information, p. 14531 - 14535 (2017/10/18)
A C?N bond forming dearomatization protocol with broad scope is outlined. Specifically, bifunctional amino reagents are used for sequential nucleophilic and electrophilic C?N bond formations, with the latter effecting the key dearomatization step. Using t
Highly stereoselective imidazolethiones mediated Friedel-Crafts alkylation of indole derivatives
Liang, Xianrui,Li, Shuangmin,Su, Weike
supporting information; experimental part, p. 289 - 291 (2012/01/31)
The asymmetric Friedel-Crafts alkylation of indoles with α,β-unsaturated aldehydes was promoted by the novel imidazolethiones to afford the corresponding adducts in moderate to excellent yields and high enantioselectivities under mild reaction conditions.
CaSH organocatalysis: Enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated aldehydes
Tian, Tian,Pei, Bao-Jian,Li, Qing-Hua,He, Hao,Chen, Ling-Yan,Zhou, Xiang,Chan, Wing-Hong,Lee, Albert W. M.
experimental part, p. 2115 - 2118 (2011/03/22)
Enantioselective Friedel-Crafts alkylation of indole with α,β-unsaturated aldehyde was catalyzed by camphor sulfonyl hydrazine (CaSH) with good enantioselectivity (81-88%). Georg Thieme Verlag Stuttgart.
Enantioselective organocatalytic indole alkylations. Design of a new and highly effective chiral amine for iminium catalysis
Austin, Joel F.,MacMillan, David W. C.
, p. 1172 - 1173 (2007/10/03)
The indole framework has become widely identified as a "privileged" structure with representation in over 3000 natural isolates and 40 medicinal agents of diverse therapeutic action. A new strategy for asymmetric access to this important pharmacaphore has
1-indolyalkyl-4-(substituted-pyridinyl)piperazines
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, (2008/06/13)
A series of 1,4-disubstituted piperazine derivatives comprised of indol-3-ylalkyl and substituted pyridin-2-yl substituent groups. These compounds are useful as antidepressant agents.
