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Usage

Uses

Used in Pharmaceutical Industry:
L-SERINE(3-13C) is used as a labeled compound for the synthesis of purines and pyrimidines, which are essential components of nucleic acids and have potential applications as antibacterial and antifungal agents. The incorporation of the 13C isotope enables researchers to study the metabolic pathways and mechanisms of action of these compounds, leading to the development of more effective and targeted therapies.
Used in Biochemical Research:
As a proteinogenic compound, L-SERINE(3-13C) is utilized in biochemical research to investigate the role of L-Serine in protein synthesis and its interactions with other biomolecules. The stable isotope labeling allows for the tracking of L-Serine within complex biological systems, providing valuable insights into its metabolic fate and function.
Used in Metabolic Studies:
L-SERINE(3-13C) is employed in metabolic studies to explore the metabolic pathways and fluxes involving L-Serine in various organisms. The use of the 13C-labeled compound allows for the differentiation between endogenous and exogenous sources of L-Serine, enabling researchers to gain a deeper understanding of its metabolic role and regulation.

Upstream product

• 1423441-96-6 [1-¹³C]-6-deoxy-6-sulfo-D-glucopyranose 
• 1423425-09-5 [1-¹³C]fructofuranose 6-phosphate 
• 172611-92-6 <3-13C>-O-benzyl-L-serine methyl ester 

Relevant academic research and scientific papers

The metabolic and biochemical impact of glucose 6-sulfonate (sulfoquinovose), a dietary sugar, on carbohydrate metabolism

Increased activity of the main carbohydrate pathways (glycolysis, pentose phosphate, and hexosamine biosynthetic pathways) is one of the hallmarks of metabolic diseases such as cancer. Sulfoquinovosyl diacylglycerol is a sulfoglycolipid found in the human

The metabolic and biochemical impact of glucose 6-sulfonate (sulfoquinovose), a dietary sugar, on carbohydrate metabolism

Increased activity of the main carbohydrate pathways (glycolysis, pentose phosphate, and hexosamine biosynthetic pathways) is one of the hallmarks of metabolic diseases such as cancer. Sulfoquinovosyl diacylglycerol is a sulfoglycolipid found in the human

Enantioselective synthesis of isotopically labelled L-α-amino acids preparation of 13C-, 18O- and 2H-labelled L-serines and L-threonines

[3-18O]-L-serine, [3-13C]-L-serine, [3-18O]-L-threonine, [3,4-13C2]-L-threonine and [3-2H]-L-threonine are prepared from simple commercially available, isotopically enriched starting materials like H218O, [13C] paraformaldehyde, [13C2]-acetaldehyde and (1-2H]-acetaldehyde. The introduction of the side chain is based on the reaction of the anion of the bislactimether of cyclo-(D-Val-Gly) with a suitable reagent. For serine this is isotopically labelled benzylchloromethylether, whereas for threonine labelled acetaldehyde is used in combination with chlorotitaniumtris[diethylamide], introducing both stereocentres in one single step. The isotopomers of serine and threonine are obtained on the gram scale in good yields and high enantiomeric and diasteriomeric excesses. New syntheses for [18O]-benzylalcohol and isotopically enriched benzylchloromethylether are reported. Following the presented synthetic scheme these amino acids can be labelled at any position or at any combination of positions.