89236-89-5

Upstream product

• 1680-44-0 5-phenyl-1H-1,2,3-triazole 
• 536-74-3 phenylacetylene 
• 16433-96-8 2-ethynyl-1-nitrobenzene 
• 5670-66-6 1-nitro-2-(2-nitrovinyl)benzene 
• 75-52-5 nitromethane 
• 552-89-6 2-nitro-benzaldehyde 
• 872700-75-9 2,2-dimethyl-propionic acid 4-(2-nitro-phenyl)-[1,2,3]triazol-1-ylmethyl ester 

Downstream Products

• 89221-20-5 4-(1H-1,2,3-triazol-4-yl)-aniline 

Relevant academic research and scientific papers

Silica immobilized copper N-heterocyclic carbene: An effective route to 1,2,3-triazoles via azide-alkyne cycloaddition and multicomponent click reaction

A new silica supported copper N-heterocyclic carbene (Cu-NHC@SiO2) complex is prepared and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) analyses. This complex is an efficient and easily retrievable catalyst for 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition reaction as well as one-pot reaction using arylboronic acids. This catalytic system is also suitable for synthesis of 4-aryl-NH-1,2,3-triazoles from diverse benzaldehydes. Further, the catalyst can efficiently be recycled up to fifth cycle for all the three methods of 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition and multi-component reactions.

On Water Cu@g-C3N4 Catalyzed Synthesis of NH-1,2,3-Triazoles via [2+3] Cycloadditions of Nitroolefins/Alkynes and Sodium Azide

Here, we have reported fabrication of graphitic polymeric C3N4 supported CuCl2 (Cu@g-C3N4) and characterized by powder X-ray diffraction, field emission scanning electron microscopy, high resolution transmission electron microscopy, X-ray photoelectron spectroscopy studies. An efficient and regioselective protocol for the on water synthesis of 4-aryl-NH-1,2,3-triazole derivatives via 1,3-diipolar cycloaddition reactions of nitroolefins/phenylacetylenes to sodium azide were demonstrated by using Cu@g-C3N4 as robust and reusable catalyst.

DABCO-mediated aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to cycloalkenones. Regioselective synthesis of disubstituted 1,2,3-triazoles

Aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to 2-cycloalken-1-ones has been studied in the presence of DABCO as organic base. The reactions were carried out in acetonitrile at room temperature to provide 2,4-disubstituted 2H-1,2,3-triazoles as major

Direct Synthesis of N-Unsubstituted 4-Aryl-1,2,3-triazoles Mediated by Amberlyst-15

A highly efficient and effective method for the synthesis of N-unsubstituted 4-aryl-1,2,3-triazoles promoted by Amberlyst-15 is described. The promoter can be recycled and reused up to eight times without any reduction in its catalytic activity.

Efficient synthesis of 2-substituted-1,2,3-triazoles

(Chemical Equation Presented) In this three-component reaction, alkynes undergo a copper(I)-catalyzed cycloaddition with sodium azide and formaldehyde to yield 2-hydroxymethyl-2H-1,2,3-triazoles, which are useful intermediates that can be readily converte

NH-1,2,3-triazoles from azidomethyl pivalate and carbamates: Base-labile N-protecting groups

NH-1,2,3-triazoles have been prepared via the copper(I)-catalyzed 1,3-dipolar cycloaddition between terminal alkynes and three N-protected organic azides, azidomethyl pivalate, azidomethyl morpholine-4-carboxylate, and azidomethyl N,N-diethylcarbarnate. T

Triazole compound and use thereof

A triazole compound or a pharmacologically acceptable salt thereof represented by the following formula (I) STR1 wherein R1 and R2 are the same or different from each other and each represents a hydrogen atom, a halogen atom or a Cs

Synthesis and in vitro antiinflammatory activity of 4-phenyl-1,2,3-triazole derivatives

This paper describes the preparation of new 4-phenyl-1,2,3-triazole derivatives of the general formulas I, II, and III, and their evaluation as in vitro prostaglandin synthesis inhibitors. These compounds generally inhibit the arachidonic acid-induced mal