892398-08-2Relevant academic research and scientific papers
Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis
Garzan, Atefeh,Willby, Melisa J.,Green, Keith D.,Tsodikov, Oleg V.,Posey, James E.,Garneau-Tsodikova, Sylvie
, p. 1219 - 1221 (2016)
Drug-resistant tuberculosis (TB) is a global threat and innovative approaches such as using adjuvants of anti-TB therapeutics are required to combat it. High-throughput screening yielded two lead scaffolds of inhibitors of Mycobacterium tuberculosis (Mtb)
EIS INHIBITORS
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Paragraph 0019; 0125, (2018/06/30)
Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.
Synthesis of annelated azaheterocycles containing a 5-carbamoylpyrazin-3- one fragment by a modification of the four-component Ugi reaction
Ilyin, Alexey P.,Kobak, Vladimir V.,Dmitrieva, Irina G.,Peregudova, Yulia N.,Kustova, Veronika A.,Mishunina, Yulia S.,Tkachenko, Sergey E.,Ivachtchenko, Alexandre V.
, p. 4670 - 4679 (2007/10/03)
A convenient synthesis of novel imidazole- and pyrrole-fused 1-oxo-1,2,3,4-tetrahydropyrazine heterocyclic structures by a novel modification of the four-component Ugi condensation is described. The usefulness and versatility of the developed approach for the synthesis of variously substituted compounds is demonstrated and the scope and limitations of the chemistry involved are discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
