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CAS

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892403-81-5

7-[3-(4-fluoro-piperidin-1-yl)-propoxy]-4-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 892403-81-5 Structure

  • Basic information

    1. Product Name: 7-[3-(4-fluoro-piperidin-1-yl)-propoxy]-4-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline
    2. Synonyms: 7-[3-(4-fluoro-piperidin-1-yl)-propoxy]-4-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline
    3. CAS NO:892403-81-5
    4. Molecular Formula:
    5. Molecular Weight: 412.548
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 892403-81-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 7-[3-(4-fluoro-piperidin-1-yl)-propoxy]-4-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-[3-(4-fluoro-piperidin-1-yl)-propoxy]-4-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline(892403-81-5)
    11. EPA Substance Registry System: 7-[3-(4-fluoro-piperidin-1-yl)-propoxy]-4-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline(892403-81-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 892403-81-5(Hazardous Substances Data)

892403-81-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 892403-81-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,2,4,0 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 892403-81:
(8*8)+(7*9)+(6*2)+(5*4)+(4*0)+(3*3)+(2*8)+(1*1)=185
185 % 10 = 5
So 892403-81-5 is a valid CAS Registry Number.

892403-81-5Downstream Products

892403-81-5Relevant articles and documents

Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore

Keith, John M.,Gomez, Leslie A.,Letavic, Michael A.,Ly, Kiev S.,Jablonowski, Jill A.,Seierstad, Mark,Barbier, Ann J.,Wilson, Sandy J.,Boggs, Jamin D.,Fraser, Ian C.,Mazur, Curt,Lovenberg, Timothy W.,Carruthers, Nicholas I.

, p. 702 - 706 (2007/10/03)

A series of tetrahydroisoquinolines acting as dual histamine H3/serotonin transporter ligands is described. A highly regio-selective synthesis of the tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

Letavic, Michael A.,Keith, John M.,Jablonowski, Jill A.,Stocking, Emily M.,Gomez, Leslie A.,Ly, Kiev S.,Miller, Jennifer M.,Barbier, Ann J.,Bonaventure, Pascal,Boggs, Jamin D.,Wilson, Sandy J.,Miller, Kirsten L.,Lord, Brian,McAllister, Heather M.,Tognarelli,Wu, Jiejun,Abad, Marta C.,Schubert, Carsten,Lovenberg, Timothy W.,Carruthers, Nicholas I.

, p. 1047 - 1051 (2007/10/03)

A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H3 ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.

TETRAHYDROISOQUINOLINE COMPOUNDS FOR TREATMENT OF CNS DISORDERS

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Page/Page column 55-56, (2010/11/08)

Certain tetrahydroisoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor-and serotonin-mediated diseases.

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