892405-58-2Relevant academic research and scientific papers
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors
Letavic, Michael A.,Keith, John M.,Jablonowski, Jill A.,Stocking, Emily M.,Gomez, Leslie A.,Ly, Kiev S.,Miller, Jennifer M.,Barbier, Ann J.,Bonaventure, Pascal,Boggs, Jamin D.,Wilson, Sandy J.,Miller, Kirsten L.,Lord, Brian,McAllister, Heather M.,Tognarelli,Wu, Jiejun,Abad, Marta C.,Schubert, Carsten,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 1047 - 1051 (2007/10/03)
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H3 ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.
