89245-37-4

Usage

Uses

Used in Pharmaceutical Industry:
(4-Bromo-1H-indol-3-yl)-acetic acid methyl ester is used as a building block for the production of drugs, owing to its unique chemical structure and reactivity. The bromine atom allows for further functionalization and modification, making it a valuable component in the development of new pharmaceutical compounds.
Used in Agricultural Industry:
In the agricultural sector, (4-Bromo-1H-indol-3-yl)-acetic acid methyl ester is utilized as a precursor in the synthesis of pesticides. Its chemical properties contribute to the development of effective and targeted pest control agents.
Used in Research Laboratories:
(4-Bromo-1H-indol-3-yl)-acetic acid methyl ester also serves as a reagent in research laboratories, where it is employed in the synthesis of complex organic molecules. Its versatility and reactivity make it a valuable tool for scientists working on the development of novel chemical entities and materials.

Upstream product

• 1448699-31-7 C₁₈H₁₆BrN₃O₄S 
• 425640-16-0 methyl 2-(4-bromo-1H-indol-3-yl)-2-oxoacetate 
• 52488-36-5 4-bromo-1H-indole 
• 960148-53-2 2-(4-bromo-1H-indol-3-yl)-2-oxoacetyl chloride 
• 89245-41-0 4-bromo-3-indoleacetic acid 

Downstream Products

• 908135-38-6 methyl [4-((E)-2-{4-[(4-phenylbutyl)oxy]phenyl}ethenyl)-1H-indole-3-yl]acetate 

Relevant academic research and scientific papers

DERIVATIVES OF AZA ADAMANTANE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

DERIVATIVES OF AZA ADAMANTANE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

INDOLE COMPOUND AND USE THEREOF

A compound represented by the general formula (I) or a salt or solvate thereof or a prodrug thereof. The compound or the salt or solvate thereof or the prodrug thereof has a leukotriene receptor antagonistic effect which is expected to be more effective than those of the leulotriene receptor antagonists currently used in clinical medicine and, therefore, is useful as an agent for prevention and/or treatment of a leukotriene-mediated disease such as a respiratory disease (e.g., bronchial asthma, chronic obstructive pulmonary disease, pulmonary emphysema, chronic bronchitis, pneumonia (e.g., interstitial pneumonia), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g., acute sinusitis, chronic sinusitis) or the like, an expectorant or an antitussive. (I) wherein all of the symbols are as defined in the description.