892455-34-4Relevant academic research and scientific papers
Synthesis of polycyclic indole skeletons by a gold(I)-catalyzed cascade reaction
Wang, Tao,Shi, Shuai,Pflaesterer, Daniel,Rettenmeier, Eva,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
supporting information, p. 292 - 296 (2014/01/17)
The conversion of simple, easily available urea-substituted 3-phenylpropargyl alcohols catalyzed by a simple IPr-gold(I) catalyst in a gold(I)-catalyzed cascade reaction composing of a gold-catalyzed nucleophilic addition and a subsequent gold-catalyzed s
Continuous recycling of homogeneous Pd/Cu catalysts for cross-coupling reactions
Sharma, Siddharth,Basavaraju,Singh, Ajay K.,Kim, Dong-Pyo
supporting information, p. 3974 - 3977 (2014/08/18)
Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck's LTD4 antagonist "Singulair" with efficient continuous homogeneous catalyst recycling.
Ligand-free palladium assisted insertion of isocyanides to urea derivatives for cascade synthesis of phenylamino-substituted quinazolinones
Sharma, Siddharth,Jain, Abhilasha
supporting information, p. 6051 - 6054 (2015/01/09)
Palladium catalyzed cascade coupling of substituted urea derivatives and tert-butyl isocyanide for the efficient synthesis of phenylamino-substituted quinazolinones has been developed in moderate to good yields. This method provides a short and alternative approach for the synthesis of quinazolinones derivatives which are valuable compounds with biological and pharmacological potentials. A plausible mechanistic scheme is proposed.
Platinum-catalyzed consecutive C-N bond formation-[1,3] shift of carbamoyl and ester groups
Nakamura, Itaru,Sato, Yusuke,Konta, Sayaka,Terada, Masahiro
supporting information; experimental part, p. 2075 - 2077 (2009/09/05)
The reaction of ortho-alkynylphenylureas 1 having a carbamoyl group attached to the nitrogen atom proceeded in the presence of catalytic amounts of PtI4, affording corresponding indole-3-carbamides 2 in moderate to high yields. In addition, the platinum-catalyzed cyclization of ortho-alkynylphenyl carbamates 3 afforded corresponding indole-3-carboxylates 4 in good yields. The present reaction proceeds through the intramolecular addition of carbon-nitrogen bonds to triple bonds, the so-called carboamination.
