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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Bromo-1-methyl-1H-indole is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Dye Manufacturing:
As an intermediate in the manufacturing of dyes, 2-Bromo-1-methyl-1H-indole contributes to the production of a wide range of colorants used in various industries, including textiles, plastics, and printing inks.
Used in Medicinal Chemistry and Drug Discovery:
Due to its structural and chemical properties, 2-Bromo-1-methyl-1H-indole has potential applications in medicinal chemistry and drug discovery. Researchers can utilize 2-broMo-1-Methyl-1H-Indole to explore new drug candidates and develop innovative therapeutic agents.

Upstream product

• 75833-63-5 2-iodo-1-methyl-1H-indole 
• 603-76-9 1-methylindole 

Downstream Products

• 603-76-9 1-methylindole 
• 65136-46-1 1-Methyl-2-isopropylindole 
• 133165-98-7 1-methyl-2-n-propyl-1H-indole 

Relevant academic research and scientific papers

Stereoselective synthesis of spirocyclic oxindoles based on a one-pot Ullmann coupling/Claisen rearrangement and its application to the synthesis of a hexahydropyrrolo[2,3-b]indole alkaloid

An efficient and convenient approach to the synthesis of spirocyclic oxindoles from iodoindoles has been developed. The most striking feature of this approach is that the sequential intramolecular Ullmann coupling and Claisen rearrangement proceeds in a one-pot manner to afford 3-spiro-2-oxindoles in good yield with excellent diastereoselectivity. Application of this one-pot reaction to chiral non-racemic tertiary alcohol substrates resulted in complete chirality transfer to the spirocyclic quaternary carbon. Using this method, asymmetric total synthesis of (-)-debromoflustramine B was accomplished.

Highly diastereoselective one-pot synthesis of spirocyclic oxindoles through intramolecular Ullmann coupling and Claisen rearrangement

(Chemical Equation Presented) An efficient and convenient approach to the synthesis of spirocyclic oxindoles from iodoindoles involves a sequential intramolecular C-O Ullmann coupling reaction and Claisen rearrangement (see scheme). The one-pot procedure affords 3-spiro-2-oxindoles in good yield with excellent diastereoselectivities.