892489-52-0

Basic information

• Product Name: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
• Synonyms: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid;AZD-3988
• CAS NO: 892489-52-0
• Molecular Formula: C₂₃H₂₂F₂N₄O₄
• Molecular Weight: 456.447
• Mol File: 892489-52-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.402
• Refractive Index: 1.627
• PKA: 4.72±0.10(Predicted)
• CAS DataBase Reference: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid(892489-52-0)
• EPA Substance Registry System: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid(892489-52-0)

Safety Data

• Hazardous Substances Data: 892489-52-0(Hazardous Substances Data)

Usage

Uses

AZD 3988 is a diacylglycerol O-acyltransferase (DGAT) enzyme inhibitor, which has been investigated as potential treatments for diabetes and other metabolic diseases.

InChI:InChI=1/C23H22F2N4O4/c24-18-10-9-17(12-19(18)25)27-23-29-28-22(33-23)21(32)26-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-20(30)31/h5-10,12-14H,1-4,11H2,(H,26,32)(H,27,29)(H,30,31)/t13-,14-

Upstream product

• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 
• 959861-91-7 C₂₈H₂₉NO₂ 
• 892491-69-9 methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate 
• 701232-68-0 (trans)-methyl 2-(4-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)cyclohexyl)acetate 
• 701232-67-9 trans-[4-(4-hydroxyphenyl)cyclohexyl]acetic methyl ester 
• 892491-68-8 trans-[4-(4-aminophenyl)cyclohexyl]acetic acid methyl ester 
• 701232-66-8 [4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester 
• 892491-67-7 methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}phenyl)cyclohexyl]acetate 
• 892489-51-9 methyl (trans-4-{4-[({5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetate 

Relevant articles and documents

CRYSTALLINE FORM OF (TRANS-4- [ ( { 5- [ (3, 4 -DI FLUOROPHENYL) AMINO] -1,3, 4-OXADIAZOL-2-YL}CARBONYL) AMINO] PH ENYL } CYCLOHEXYL) ACETIC ACID

Novel crystalline forms of the compound (trans-4- {4-[({5-[(3,4-difluorophenyl)amino]- 1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetic acid are provided, together with processes for the manufacture of such forms, pharmaceutical compositions c