892501-15-4Relevant academic research and scientific papers
Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus
Jana, Santanu,Sarpe, Vikram A.,Kulkarni, Suvarn S.
, p. 6938 - 6942 (2018/10/25)
Fungal glycolipids emmyguyacins A and B inhibit the pH-dependent conformational change of hemaglutinin A during replication of the Influenza virus. Herein, we report the first total synthesis and structure confirmation of emmyguyacins A and B. Our efficient route, which involves regioselective functionalization of trehalose, allows rapid access to adequate amounts of chemically pure emmyguyacin analogues including the desoxylate derivatives for SAR studies.
Synthesis of trans-vaccenic acid and cis-9-trans-11-conjugated linoleic acid
Duffy, Patricia E.,Quinn, Sonia M.,Roche, Helen M.,Evans, Paul
, p. 4838 - 4843 (2007/10/03)
The preparation of the monounsaturated fatty acid, trans-vaccenic acid 4 (TVA), using both Wittig and one-pot Julia-Kocieński olefination protocol, was achieved in good yield. Similarly a Wittig approach was employed for the stereoselective synthesis of cis-9-trans-11-conjugated linoleic acid 2 from trans-2-nonenal and (8-carboxyoctyl)triphenylphosphonium bromide 12.
