892502-27-1

Basic information

• Product Name: 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile
• Synonyms: 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile;2-(2-methylimidazol-1-yl)benzonitrile
• CAS NO: 892502-27-1
• Molecular Formula: C₁₁H₉N₃
• Molecular Weight: 183.20926
• Mol File: 892502-27-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 102 °C
• Appearance: /
• CAS DataBase Reference: 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile(892502-27-1)
• EPA Substance Registry System: 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile(892502-27-1)

Safety Data

• Hazardous Substances Data: 892502-27-1(Hazardous Substances Data)

Usage

General Description

2-(2-Methyl-1H-imidazol-1-yl)benzonitrile is a chemical compound with the molecular formula C11H10N2. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile is known for its unique structural properties, which make it a versatile building block for the creation of a wide variety of molecular structures. It is also used in research and development as a precursor to a range of organic compounds. Additionally, it can be used in the development of new materials and as a reagent in organic synthesis. Overall, 2-(2-Methyl-1H-imidazol-1-yl)benzonitrile is a valuable chemical compound with a wide range of applications in various industries.

Upstream product

• 693-98-1 2-methylimidazole 
• 394-47-8 2-fluorobenzonitrile 

Downstream Products

• 159589-71-6 2-(2-methyl-imidazol-1-yl)-benzoic acid 

Relevant articles and documents

Preparation of highly potent and selective non-peptide antagonists of the arginine vasopressin V1A receptor by introduction of a 2-ethyl-1H-1-imidazolyl group

To find a new series of arginine vasopressin (AVP) V1A receptor antagonists, the influence of the 2-phenyl group of 2-phenyl-4′-[(2,3,4,5- tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide (7) was investigated. Replacement of the 2-phenyl group by a 2-ethyl-1H-imidazol-1-yl group was effective in yielding a V1A-selective compound. Moreover, this imidazolyl group was introduced in the same position in YM-35471 (6), and further studies of these compounds were performed. Consequently, we found that the (Z)-4′-({4,4-difluoro-5-[(N-cyclo-propylcarbamoyl) methylene]-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl}carbonyl)-2-(2-ethyl-1H-1- imidazol-1-yl)benzanilide (9f) exhibited highly potent affinity and selectivity, and was the most potent antagonist for the V1A receptor among our compounds. The synthesis and pharmacological evaluation of these compounds are described in this paper