892546-37-1

Basic information

• Product Name: PH-064
• Synonyms: PH-064;IMidazo[1,2-a]pyrazine, 7,7'-[dithiobis[(2R)-2-aMino-1-oxo-3,1-propanediyl]]bis[8-(cyclohexylMethyl)-5,6,7,8-tetrahydro-2-phenyl-, (8S,8'S)- (9CI)
• CAS NO: 892546-37-1
• Molecular Formula: C₄₄H₅₈N₈O₂S₂
• Molecular Weight: 795.11372
• Mol File: 892546-37-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1024.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 6.74±0.33(Predicted)
• CAS DataBase Reference: PH-064(CAS DataBase Reference)
• NIST Chemistry Reference: PH-064(892546-37-1)
• EPA Substance Registry System: PH-064(892546-37-1)

Safety Data

• Hazardous Substances Data: 892546-37-1(Hazardous Substances Data)

Usage

General Description

PH-064 is a chemical compound commonly used in the pharmaceutical industry as a potential treatment for various diseases. It belongs to the class of small molecule inhibitors and has been shown to inhibit the activity of specific enzymes or receptors. PH-064 has undergone preclinical studies and has shown promising results in the inhibition of certain targets involved in the progression of diseases such as cancer and autoimmune disorders. It is also being explored for its potential anti-inflammatory and immunomodulatory properties. Further research and clinical trials are required to fully understand the therapeutic potential and safety profile of PH-064 for various conditions.

Upstream product

• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 

Relevant articles and documents

Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation as Gαq-Protein Ligands

The 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine derivative BIM-46174 and its dimeric form BIM-46187 (1) are heterocyclized dipeptides that belong to the very few cell-permeable compounds known to preferentially silence Gαq proteins. To explore the chemical space of Gαq inhibitors of the BIM chemotype, a combinatorial approach was conducted towards a library of BIM molecules. This library was evaluated in a second messenger-based fluorescence assay to analyze the activity of Gαq proteins through the determination of intracellular myo-inositol 1-phosphate. Structure–activity relationships were deduced and structural requirements for biological activity obtained, which were (i) a redox reactive thiol/disulfane substructure, (ii) an N-terminal basic amino group, (iii) a cyclohexylalanine moiety, and (iv) a bicyclic skeleton. Active compounds exhibited cellular toxicity, which was investigated in detail for the prototypical inhibitor 1. This compound affects the structural cytoskeletal dynamics in a Gαq/11-independent manner.