892596-58-6

Basic information

• Product Name: N-(2-chlorobenzyl)prop-2-yn-1-amine
• Synonyms: benzenemethanamine, 2-chloro-N-2-propyn-1-yl-
• CAS NO: 892596-58-6
• Molecular Formula: C₁₀H₁₀ClN
• Molecular Weight: 179.6461
• Mol File: 892596-58-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 278.5°C at 760 mmHg
• Flash Point: 122.2°C
• Density: 1.124g/cm³
• Vapor Pressure: 0.00425mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: N-(2-chlorobenzyl)prop-2-yn-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chlorobenzyl)prop-2-yn-1-amine(892596-58-6)
• EPA Substance Registry System: N-(2-chlorobenzyl)prop-2-yn-1-amine(892596-58-6)

Safety Data

• Hazardous Substances Data: 892596-58-6(Hazardous Substances Data)

Upstream product

• 106-96-7 propargyl bromide 
• 89-97-4 2-CHLOROBENZYLAMINE 

Relevant articles and documents

Pyridone hexa-alkyne amine modified derivative and preparation method and application thereof

The invention relates to a pyridone hexa-alkyne amine modified derivative as shown in a formula (I) and a pharmaceutically acceptable salt thereof, a preparation method thereof, application of the pyridone hexa-alkyne amine modified derivative or the pharmaceutically acceptable salt thereof to preparation of drugs for preventing or treating related diseases, especially Alzheimer's disease and Parkinson's disease, by inhibiting monoamine oxidase, chelating metal iron ions, resisting Abeta and resisting oxidation. According to the invention, a series of novel single-molecule multi-target anti-ADactive compounds are synthesized, and pyridone derivatives with iron ion chelating activity and propynylamine with MAOB inhibitory activity are creatively and organically combined together, so that the compounds have remarkable advantages on Alzheimer's disease with complex pathogenesis; and the combined molecules are far superior to CP20 (deferiprone) in the aspect of iron ion chelating activity.

One-pot, two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazoles

A facile, one-pot two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazole derivatives has been developed. The protocol employs an N-allylation of N-propargylated amines with 2,3-dibromopropene in the presence of K2CO3 in DMSO and a CuI-catalyzed [3 + 2] cycloaddition reaction of the synthetic N-(2-bromoallyl)-N-propargyl amines with sodium azide sequentially. Such a method provides methylene-substituted 1,2,3-triazole fused piperazines with some advantages such as simple operation, high efficiency and good product yield (80–91%) through readily available starting materials.