89263-29-6Relevant academic research and scientific papers
Carbamoylation of imidazo [4,5-f] 6H quinoline-9-ones and 9-amino imidazo [4,5-f] quinolines: Antiparasitic, antimicrobial and antifungal studies
Chaoui,Giorgi Renault,Renault,et al.
, p. 535 - 540 (2007/10/02)
Carbamylation by dimethylcarbamyl chloride of 3-methylimidazo[4,5-f]6H-quinoline-9-one occurs either at the oxygen atom in position 9 or at the nitrogen atom in position 6, according to steric hindrance of the carbon atom in position 8. If positions 3 or 8 are free, the result is decarbamylation at positions 3 and O-9; if there is a chlorine atom in position 8, three carbamylates can be isolated with substitution at 1,3 and 6,3 and O-9 respectively. A description is given of carbamylation by methyl isocyanate and dimethylcarbamyl chloride of 9-aminoimidazo-[4,5-f]quinolines. Amoebicide and trichonomicide activity of nine derivatives was tested as well as germicidal and fungicidal activity of eighteen compounds. Carbamyl groups were found to inhibit biological activity.
