89270-46-2Relevant academic research and scientific papers
Pyrazolecarboxylic acid hydrazides as antiinflammatory agents. New selective lipoxygenase inhibitors
Tihanyi,Feher,Gal,et al.
, p. 433 - 439 (2007/10/02)
The synthesis and antiinflammatory activity of some new pyrazolecarboxylic acid hydrazides 3, 4 and 5 substituted with alkyl, alkylidene, aryl and acyl groups are described. 3 were prepared by reaction of pyrazolecarboxylic acids, esters, acid chlorides or diketopiperazines with hydrazines. Upon reaction with carbonyl compounds 3 gave hydrazones 4. Acylation of 3 yielded mono or bisacyl compounds 5. The most potent antiinflammatory compounds were among the N'-aryl hydrazides. These showed high lipoxygenase inhibitory activity but hardly inhibited cyclooxygenase enzyme.
