89280-05-7Relevant academic research and scientific papers
Pyrimidine derivative, preparation method thereof, application , and pharmaceutical composition
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Paragraph 0075-0080, (2021/01/29)
The invention relates to the technical field of chemical medicines and relates to a pyrimidine derivative, a preparation method thereof, application and a pharmaceutical composition. The structural formula of the pyrimidine derivative is shown in the specification, wherein R1 and R1'are respectively and independently selected from any one of substituted or unsubstituted alkyl, H and substituted orunsubstituted naphthenic base, R2 and R2'are respectively and independently selected from any one of H, substituted or unsubstituted alkyl, substituted or unsubstituted naphthenic base, halogen, -NH2, -NO2 and -CN, R3, R3 ', R4 and R4' are respectively and independently selected from any one of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and Y-X. The novel pyrimidine derivative has an excellent inhibitory effect on kinase, and particularly has a remarkable inhibitory effect on PLK4, and the novel pyrimidine derivative can inhibit tumor growth.
