89284-38-8Relevant academic research and scientific papers
BIARYL DERIVATIVE AS GPR120 AGONIST
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Paragraph 0489, (2017/11/17)
The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.
Studies on the regioselective nucleophilic aromatic substitution (S NAr) reaction of 2-substituted 3,5-dichloropyrazines
Scales, Stephanie,Johnson, Sarah,Hu, Qiyue,Do, Quyen-Quyen,Richardson, Paul,Wang, Fen,Braganza, John,Ren, Shijian,Wan, Yadong,Zheng, Baojiang,Faizi, Darius,McAlpine, Indrawan
supporting information, p. 2156 - 2159 (2013/06/05)
Differences in regioselectivity were observed during the SNAr reaction of amines with unsymmetrical 3,5-dichloropyrazines. This study revealed that when the 2-position of the pyrazine was occupied with an electron-withdrawing group (EWG), nucle
6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS
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Page/Page column 106-107, (2010/04/03)
The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.
THERAPEUTIC COMPOUNDS
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Page/Page column 67, (2009/05/30)
The present invention relates to pyrazine substituted pyrrolopyridines which are inhibitors of JAK kinases (JAKl, JAK2, JAK3 and/or TYK2) and/or PDKl and are thus useful for the treatment of myeloproliferative disorders or cancer.
PYRAZINE-BASED TUBULIN INHIBITORS
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Page 49, (2010/02/07)
A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating a hyperproliferation-related disease state or disorder in a subject using a compound of formula (I) is also described
Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
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Page 17, (2010/02/05)
Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological diso
