89284-61-7

Basic information

• Product Name: 4-Chloro-3-cyanopyridine
• Synonyms: 4-CHLORO-NICOTINONITRILE;4-CHLORO-3-CYANOPYRIDINE;4-CHLORO-3-CYANOPYRIDINE 98%;4-Chloro-3-pyridinecarbonitrile;4-Chloropyridine-3-carbonitrile;Nicotinonitrile,4-Chloro-(7CI);4-Chloro-3- cyanopyridine,4-chloronicotinonitrile;4-Chloro-pyridin-3-carbonitrile
• CAS NO: 89284-61-7
• Molecular Formula: C₆H₃ClN₂
• Molecular Weight: 138.55
• Product Categories: Heterocyclic Compounds
• Mol File: 89284-61-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 243.552 °C at 760 mmHg
• Flash Point: 101.097 °C
• Appearance: /
• Density: 1.331 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 1.11±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-cyanopyridine(89284-61-7)
• EPA Substance Registry System: 4-Chloro-3-cyanopyridine(89284-61-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 89284-61-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 89284-61-7 differently. You can refer to the following data:
1. 4-Chloro-3-cyanopyridine is used in the preparation of heteroaryl urea inhibitors.
2. 4-Chloro-3-pyridinecarbonitrile is used in the preparation of heteroaryl urea inhibitors.

Upstream product

• 1986-81-8 nicotinamide N-oxide 
• 100-54-9 pyridine-3-carbonitrile 
• 14906-64-0 3-cyanopyridine N-oxide 

Downstream Products

• 7418-70-4 4-chloropyridine-3-carboxyamide 
• 1430745-35-9 (1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-31-1 (1R,3s,5S)-tert-butyl 3-((1s,4S)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430746-27-2 (1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride 
• 1430745-40-6 (1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430746-26-1 (1R,3s,5S)-1-methylcyclopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride 
• 1430745-39-3 (1R,3s,5S)-1-methylcyclopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430745-38-2 4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile 
• 1430747-23-1 (1R,3S,5S)-((R)-1,1,1-trifluoropropan-2-yl) 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430745-36-0 (1R,3S,5S)-((S)-1,1,1-trifluoropropan-2-yl) 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-24-2 (1R,3R,5S)-((S)-1,1,1-trifluoropropan-2-yl) 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-22-0 (1R,3r,5S)-tert-butyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1430747-26-4 (1R,3r,5S)-tert-butyl 3-((1s,4S)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1415818-08-4 4-((1r,4r)-4-(1-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile 

Relevant articles and documents

Straightforward access to ethyl 3-aminofuropyridine-2-carboxylates from 1-chloro-2-cyano- or 1-hydroxy-2-cyano-substituted pyridines

The conditions of the synthesis of the four regioisomers of ethyl 3-aminofuropyridine-2-carboxylate are described and discussed in detail. The starting materials are either 1-chloro-2-cyanopyridines or 1-cyano-2- hydroxypyridines. Georg Thieme Verlag Stuttgart.

Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride

Site-selectivity in the reaction of 3-substituted pyridine 1-oxide with phosphoryl chloride was investigated.When a strongly electron-withdrawing group (e.g.CN, CONRR', COOR, or NO2) was substituted at the 3-position, the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride yielded 3-substituted 2-chloropyridines as the main products.Keywords- site-selectivity; 3-substituted pyridine 1-oxide; phosphoryl chloride; 3-substituted 2-chloropyridine; chlorination