892859-45-9Relevant academic research and scientific papers
A concise stereoselective synthesis of Preussin, 3-epi-Preussin, and analogues
Bertrand, Myra Beaudoin,Wolfe, John P.
, p. 2353 - 2356 (2006)
A new stereoselective synthesis of the antifungal and antitumor agents Preussin and 3-epi-Preussin via a Pd-catalyzed carboamination of a protected amino alcohol is described. The key transformation leads to simultaneous formation of the N-C2 bond and the C1′-aryl bond, and allows installation of the aryl group one step from the end of the sequence. This strategy permits the facile construction of a variety of preussin analogues bearing different aromatic groups.
