892874-49-6

Basic information

• Product Name: 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID
• CAS NO: 892874-49-6
• Molecular Formula: C10H6ClNO2
• Molecular Weight: 207.61
• Product Categories: CHIRAL CHEMICALS
• Mol File: 892874-49-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 382.122 °C at 760 mmHg
• Flash Point: 184.901 °C
• Appearance: /
• Density: 1.47 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: 2-8°C
• PKA: 4.39±0.25(Predicted)
• CAS DataBase Reference: 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID(892874-49-6)
• EPA Substance Registry System: 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID(892874-49-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 892874-49-6(Hazardous Substances Data)

Usage

Uses

7-Chloro-3-quinolinecarboxylic Acid is used as a reactant in the preparation of N-(het)arylmethyl)heteroaryl-carboxamides as plasma kallikrein inhibitors.

InChI:InChI=1/C10H6ClNO2/c11-8-2-1-6-3-7(10(13)14)5-12-9(6)4-8/h1-5H,(H,13,14)

Upstream product

• 89-59-8 4-chloro-2-nitrotoluene 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 133455-49-9 7-chloro-quinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

A 3 - amino -7 - chloroquinolin synthetic method (by machine translation)

The invention provides a 3 - amino - 7 - chloroquinolin synthetic method. Synthesis method of the invention, in order to 4 - chloro - 1 - methyl - 2 - nitrobenzene as the raw materials, and N, N - dimethyl formamide dimethyl acetal to hydroformylation reaction to produce 4 - chloro - 2 - nitrobenzaldehyde, with 3, 3 - diethyl oxygen radical propionic acid ethyl ester to ring-closure reaction to produce 7 - chloro - 3 - quinoline carboxylic acid ethyl ester, under basic condition to produce 7 - chloro - 3 - quinoline carboxylic acid, with the azido diphenyl phosphate through Curtius rearrangement reaction to 3 - tert-butoxycarbonyl amino - 7 - chloroquinolin, finally through takes off uncle butoxycarbonyl to obtain 3 - amino - 7 chloroquinolin. The invention of 3 - amino - 7 - chloroquinolin synthetic method, the synthetic route is simple, reasonable process, low material cost, simple and easy to obtain, operation and after treatment is convenient, the total yield is high, easy to enlarge, can be large-scale production of 3 - amino - 7 - chloroquinolin. (by machine translation)