2,3-bisaza-A-nor-1,5(10)-estradien-17-ol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.
The CAS Registry Mumber 89288-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,2,8 and 8 respectively; the second part has 2 digits, 7 and 0 respectively. Calculate Digit Verification of CAS Registry Number 89288-70: (7*8)+(6*9)+(5*2)+(4*8)+(3*8)+(2*7)+(1*0)=190 190 % 10 = 0 So 89288-70-0 is a valid CAS Registry Number.
89288-70-0SDS
SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition
Holt, Dennis A.,Levy, Mark A.,Brandt, Martin,Metcalf, Brian W.
, p. 213 - 222 (1986)
A novel A-ring pyrazole steroid, 2,3-bisaza-A-nor-1,5(10)-estradien-17β-ol (3), was synthesized as a potential inhibitor of steroidal NAD(P)H-dependent oxidoreductases.Compound (3) proved to be a potent inhibitor of 3(17)β-hydroxysteroid dehydrogenase (from P. testosteroni) exhibiting a Ki of 90 +/- 20 nM.The activities of 3α,20β-hydroxysteroid dehydrogenase (from S. hydrogenans), steroid-5α-reductase (from rat prostate), and 3α-hydroxysteroid dehydrogenase (from rat liver) were unaffected by pyrazole (3).Dead end inhibition studies indicate an ordered binding of cofactor prior to substrate or pyrazole inhibitor.
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