89316-49-4

Upstream product

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 5614-82-4 ethyl 2-(4-methyl-2-oxo-2-coumarin-7-yloxy)acetate 
• 69321-36-4 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-acetohydrazide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 1207745-36-5 C₂₅H₂₄N₂O₉S 
• 1207745-20-7 C₂₃H₂₂N₂O₇S 

Relevant academic research and scientific papers

Access to new antimicrobial 4-methylumbelliferone derivatives

Synthesis of some novel coumarin esters has been accomplished through iodine-catalyzed method using 4-methylumbelliferone as the starting material. Condensation of hydrazide, which was obtained in two steps from 4-methylumbelliferone, with some arylaldhydes provided hydrazone derivatives, while the reaction with phenylthioisocyanate leads to the thiosemicarbazide that evolved into two new compounds. Finally, condensation reaction of hydrazide with three diketones afforded new pyrrole and pyrazole derivatives. Structures of all synthesized compounds were established on the basis of spectroscopic methods including 1H NMR, 13C NMR and ES-HRMS. They were finally tested for their antimicrobial activity and the structure-activity relationship was discussed.

Synthesis and antimicrobial activity of thiazolidinones derived from 4-methylcoumarinyl-7-oxyacetic hydrazide

A series of new thiazolidin-4-ones (3a-j), 5-carboxymethyl-4- thiazolidinones (4a-1) have been synthesised via the condensation of 4-methylcoumarinyl-7-oxyacetic acid [(substituted phenyl)methylene]hydrazides (2a-1), with thioglycolic acid and thiomalic acid respectively. The compounds (2a-1) were synthesised from 4-methylcoumarinyl-7-oxyacetic hydrazide using various aromatic aldehydes. The structure of all synthesised compounds has been determined by spectral methods. The compounds were screened for their antibacterial activity against S. aureus and B. subtilis bacteria.