89329-08-8Relevant academic research and scientific papers
An efficient synthesis of the four mono methylated isomers of (+)-catechin including the major metabolites and of some dimethylated and trimethylated analogues through selective protection of the catechol ring
Cren-Olive, Cecile,Lebrun, Stephane,Rolando, Christian
, p. 821 - 830 (2002)
The four monomethylated isomers of (+)-catechin in positions 3′, 4′, 5 and 7, two dimethylated derivatives, the 5,7-dimethylcatechin and the 3′, 4′-dimethylcatechin and two trimethylated isomers of (+)-catechin in positions 3′, 5, 7 and 4′, 5, 7 were synthesized by a new method based on successive and selective protections of the various phenol functions present on (+)-catechin. The key step was the selective protection of the catechol ring with dichlorodiphenylmethane and di-tert-butyldichlorosilane.
