89333-18-6Relevant academic research and scientific papers
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
Tumey, L. Nathan,Bom, David,Huck, Bayard,Gleason, Elizabeth,Wang, Jianmin,Silver, Daniel,Brunden, Kurt,Boozer, Sherry,Rundlett, Stephen,Sherf, Bruce,Murphy, Steven,Dent, Tom,Leventhal, Christina,Bailey, Andrew,Harrington, John,Bennani, Youssef L.
, p. 277 - 281 (2005)
We describe the identification and SAR of a series of low nanomolar inhibitors of FEN1, an enzyme involved in DNA repair pathways. These inhibitors have been shown to sensitize certain cell lines to DNA damage. Flap endonuclease-1 (FEN1) is a key enzyme i
