893407-16-4

Upstream product

• 893407-14-2 ((5S)-5-{[tert.-butyl(dimethyl)silyl]oxy}-2,4-dicyclopentyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)[4-(trifluoromethyl)phenyl]-methanone 

Downstream Products

• 893407-19-7 (5S)-5-{[tert.-butyl(dimethyl)silyl]oxy}-2,4-dicyclopentyl-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinoline 

Relevant academic research and scientific papers

(5S) -3-[(S)-FLUORO (4-TRIFLUOROMETHYLPHENYL) METHYL]-5,6,7,8-TETRAHYDROQUINOLINE-5-OL DERIVATIVES AND USE THEREOF AS CETP INHIBITORS

The invention relates to novel tetrahydroquinoline derivatives of formula (I), wherein R1 represents cyclohexyl or cyclopentyl, R2 and R3 each represent methyl or jointly form a cyclobutane, and R4 represents cyclopentyl or isopropyl, the salts and solvates thereof, and the solvates of said salts. Also disclosed are a method for the production thereof, the use thereof on its own or in combinations for the treatment and/or prevention of diseases, and the use thereof for producing medicaments, particularly as a cholesterol ester transfer protein (CETP) inhibitor in order to treat and/or prevent cardiovascular diseases, especially hypolipoproteinemia, dyslipidemia, hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, and arteriosclerosis.