893413-02-0Relevant articles and documents
The conformational bias of aryl, arylsulfonyl geminally substituted tertiary carbon centers: Applications in substrate-based stereocontrol
Scott, Jeremy P.,Mullens, Peter R.,Brewer, Sarah E.,Brands, Karel M.J.,Chilenski, Jennifer R.,Davies, Antony J.,Gibb, Andrew D.,Lieberman, David R.,Oliver, Steven F.,Dolling, Ulf-H.
, p. 1806 - 1810 (2006)
Intramolecular nitrile oxide-olefin cycloaddition to form hexahydrobenzisoxazole 14, which engenders a phenylsulfonyl, 2,5-difluorophenyl geminally substituted carbon substructure, proceeds with up to 99% ds. A rationalization of the high level of substra