893424-02-7

Basic information

• Product Name: Benzenemethanol, 4-(3-phenyl-1,7-naphthyridin-2-yl)-
• CAS NO: 893424-02-7
• Molecular Formula: C21H16N2O
• Molecular Weight: 312.371
• Mol File: 893424-02-7.mol

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-(3-phenyl-1,7-naphthyridin-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-(3-phenyl-1,7-naphthyridin-2-yl)-(893424-02-7)
• EPA Substance Registry System: Benzenemethanol, 4-(3-phenyl-1,7-naphthyridin-2-yl)-(893424-02-7)

Safety Data

• Hazardous Substances Data: 893424-02-7(Hazardous Substances Data)

Upstream product

• 893424-00-5 N-formyl-N-(4-formylpyridin-3-yl')-2,2-dimethylpropanainide 
• 893423-80-8 1-[4-({[tert-butyl-(dimethyl)silyl]oxy}methyl)phenyl]-2-phenylethanone 

Downstream Products

• 893424-04-9 [4-(7-oxido-3-phenyl-1,7-naphthyridin-2-yl)phenyl]methanol 

Relevant articles and documents

INHIBITORS OF AKT ACTIVITY

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.