893440-54-5Relevant academic research and scientific papers
PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY PROTEIN KINASES FOR THE TREATMENT OF INFLAMMATORY, PROLIFERATIVE AND IMMUNOLOGICALLY-MEDIATED DISEASES
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Page/Page column 73, (2008/06/13)
This invention describes compounds of Formula (I), or a pharmaceutically accepted salt thereof, wherein each R3 and R4 is independently H, halogen or C1-4aliphatic optionally substituted with halogen, C1-2aliphatic, OCH3, NO2, NH2, CN, NHCH3, SCH3, or N(CH)2. R2 is a 3-8membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R2 is optionally substituted with JR; each X1 and X2 is independently -C(O)-, -NR-, or -SO2- wherein one of X1 or X2 is -NR- and other of X1 or X2 is -C(O)- or -SO2-; R1 and R are as described herein; These compounds are effective as inhibitors of Tec family (e.g., Tec, Btk, Itk/Emt/Tsk, Bmx, Txk/Rlk) protein kinases. These compounds and pharmaceutically acceptable compositions thereof are useful for treating or preventing a variety of diseases, disorders or conditions, including, but not limited to, an autoimmune, inflammatory, proliferative, or hyperproliferative disease or an immunologically-mediated disease.
