89364-31-8

Basic information

• Product Name: TETRAHYDRO-3-FUROIC ACID
• Synonyms: TETRAHYDRO-FURAN-3-CARBOXYLIC ACID;TETRAHYDRO-3-FUROIC ACID;RARECHEM AL BE 0888;3-Tetrahydrofuroic;3-Furancarboxylicacid,tetrahydro-(9CI);tetrahydro-3-furancarboxylic acid;3-Furancarboxylic acid, tetrahydro-;Tetrahydro-3-furoic acid ,99%
• CAS NO: 89364-31-8
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.12
• Product Categories: CARBOXYLICACID;API intermediates;Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 89364-31-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 129-130 °C
• Boiling Point: 140 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.214 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00618mmHg at 25°C
• Refractive Index: n20/D 1.4605(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Acetone, Chloroform (Slightly)
• PKA: 4.33±0.20(Predicted)
• CAS DataBase Reference: TETRAHYDRO-3-FUROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-3-FUROIC ACID(89364-31-8)
• EPA Substance Registry System: TETRAHYDRO-3-FUROIC ACID(89364-31-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 89364-31-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 89364-31-8 differently. You can refer to the following data:
1. Tetrahydro-3-furoic Acid can be used in the synthesis of anti-tumor compounds comprising of hydroxyisovalerylshikonin analogs. Furthermore, the compound is a reagent in the synthesis of class II c-Met inhibitors, in the treatment of c-Met dependant tumors.
2. Tetrahydro-3-furoic acid was used in synthesis of o-ethylphenyl tetrahydro-3-furanyl ketone.

InChI:InChI=1/C5H8O3/c6-5(7)4-1-2-8-3-4/h4H,1-3H2,(H,6,7)

Upstream product

• 130193-90-7 (S)-tetrahydro-furan-3-carboxylic acid benzyl ester 
• 1445651-64-8 tetrahydro-furan-3-carboxylic acid benzyl ester 
• 79710-86-4 tetrahydrofuran-3-carboxaldehyde 
• 124391-75-9 3-tetrahydrofuranmethanol 
• 488-93-7 3-Furoic acid 

Downstream Products

• 124391-75-9 3-tetrahydrofuranmethanol 
• 547-65-9 α-methylene-γ-butyrolactone 
• 405151-02-2 α:-acetoxymethyl-γ-butyrolactone 
• 627529-83-3 benzyl N-{(S)-2-[((R)-2,3,4,5-tetrahydro-3-{[(methyl)(phenyl)amino]carbonyl}furan-3-yl)amino]-1-methyl-2-oxoethyl}carbamate 
• 627529-84-4 benzyl N-{(S)-2-[((S)-2,3,4,5-tetrahydro-3-{[(methyl)(phenyl)amino]carbonyl}furan-3-yl)amino]-1-methyl-2-oxoethyl}carbamate 

Relevant articles and documents

Electrochemical Oxidation of Alcohols and Aldehydes to Carboxylic Acids Catalyzed by 4-Acetamido-TEMPO: An Alternative to "anelli" and "pinnick" Oxidations

An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethylpiperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.

QUINOLINE DERIVATIVES

The invention relates to quinoline compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, W, U, Q, R1, R5 R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Tempo-mediated oxidation of primary alcohols to carboxylic acids by exploitation of ethers inan aqueous-organicbiphase system

Expeditious and benign methods for primary alcohol- carboxylicacid conversions with TEMPO were developed in abiphasic system composed of aslightlymiscible ether (THP) and aqueous layer. Easily available co-oxidants such as Py-HBr3, Bu4NBr3, and electrooxidation were successfully applied to generate N-oxoammonium species as a recyclable catalyst.