89371-37-9 Usage
Description
Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for
hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from
spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE
inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone
spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at
a considerably lower dose than enalapril. This stroke preventive effect has been suggested to
be primarily by an indirect mechanism related to the amelioration of kidney dysfunction.
Chemical Properties
White Solid
Uses
Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive
Brand name
Tanatril; Novarok
Check Digit Verification of cas no
The CAS Registry Mumber 89371-37-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,3,7 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 89371-37:
(7*8)+(6*9)+(5*3)+(4*7)+(3*1)+(2*3)+(1*7)=169
169 % 10 = 9
So 89371-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1
89371-37-9Relevant articles and documents
USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS
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, (2008/06/13)
The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
ANTIHYPERTENSIVE 2-OXO-IMIDAZOLIDINE DERIVATIVES
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, (2008/06/13)
Novel 2-oxo-imidazolidine derivative of the formula: STR1 wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R. sup.3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, and a pharmaceutically acceptable salts thereof are disclsoed. Said compounds (I) and salts thereof are useful as hypotensive agents.