893746-76-4Relevant academic research and scientific papers
Nickel-Catalyzed Directed Hydroarylation of Alkynes with Boronic Acids
Hanna, Luke E.,Konev, Mikhail O.,Jarvo, Elizabeth R.
, p. 184 - 187 (2019)
A regio- and stereoselective nickel-catalyzed hydroarylation of alkynes using propargylic carbamates as directing groups has been developed. The reaction proceeds under mild reaction conditions using arylboronic acids in the absence of base. A range of heterocycles and functional groups are tolerated under the reaction conditions, providing high yields of trisubstituted alkenes with control of olefin geometry.
Nickel-Catalyzed Asymmetric Propargylic Amination of Propargylic Carbonates Bearing an Internal Alkyne Group
Watanabe, Kouichi,Miyazaki, Yusuke,Okubo, Masataka,Zhou, Biao,Tsuji, Hiroaki,Kawatsura, Motoi
supporting information, p. 5448 - 5451 (2018/09/13)
We have achieved the nickel-catalyzed asymmetric propargylic amination of propargylic carbonates bearing an internal alkyne group. A wide variety of propargylic carbonates and N-methylaniline derivatives were tolerated under the reaction conditions, providing the corresponding chiral propargylic amines in up to 97% yield with up to 97% ee.
