894-15-5Relevant articles and documents
Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids
Nguyen, Tung T.,Ngo, Bao H. T.,Le, Huy X.,Vu, Linh N. P.,To, Tuong A.,Phan, Anh N. Q.,Phan, Nam T. S.
, p. 5451 - 5455 (2021/02/12)
We report a method for addition of α-bromophenylacetic acids to vinyl C-C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO3)2·6H2O in the presence of dipivaloylmethane (dpm) ligand.
Regioselective Synthesis of γ-Lactones by Iron-Catalyzed Radical Annulation of Alkenes with α-Halocarboxylic Acids and Their Derivatives
Iwasaki, Masayuki,Miki, Natsumi,Ikemoto, Yuichi,Ura, Yasuyuki,Nishihara, Yasushi
supporting information, p. 3848 - 3852 (2018/07/25)
An abundant and low toxicity iron catalyst has enabled regioselective annulation of alkenes with α-halocarboxylic acids and their derivatives. The reaction proceeds smoothly without any additional ligands, bases, and additives to afford a variety of γ-lactones in good yields. A proposed reaction pathway through radical annulation is supported by some mechanistic studies, involving radical clock and isotope labeling experiments. The present method was applied to the practical iron-powder-promoted synthesis of γ-lactones.