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7-chloro-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one is a complex organic compound belonging to the quinazolinone class, characterized by a quinazolinone core structure with a chloro substituent at the 7th position, a methyl group at the 2nd position, and a 2-methylphenyl group at the 3rd position. 7-chloro-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one is known for its potential applications in medicinal chemistry, particularly as a precursor or intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its chemical structure provides a foundation for further functionalization and modification, which can lead to the development of new compounds with specific biological activities. The compound's properties, such as solubility, stability, and reactivity, are influenced by the presence of these functional groups, making it a versatile building block in the field of organic synthesis.

894-49-5

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894-49-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 894-49-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,9 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 894-49:
(5*8)+(4*9)+(3*4)+(2*4)+(1*9)=105
105 % 10 = 5
So 894-49-5 is a valid CAS Registry Number.

894-49-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-chloro-2-methyl-3-(2-methylphenyl)quinazolin-4-one

1.2 Other means of identification

Product number -
Other names B 182

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:894-49-5 SDS

894-49-5Downstream Products

894-49-5Relevant academic research and scientific papers

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Welch,Ewing,Huang,Menniti,Pagnozzi,Kelly,Seymour,Guanowsky,Guhan,Guinn,Critchett,Lazzaro,Ganong,DeVries,Staigers,Chenard

, p. 177 - 181 (2007/10/03)

Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure-activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the N-3 aryl group provided sufficient thermal stability for atropisomers to be isolated. Separation of these atropisomers resulted in the identification of (+)-38 (CP-465,022), a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.

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