894075-22-0

Basic information

• Product Name: ethyl 2-chloro-5-{[3-cyano-4-(4-cyanophenyl)-5-methyl-1H-pyrrol-1-yl]methyl}pyridine-3-carboxylate
• Synonyms: ethyl 2-chloro-5-{[3-cyano-4-(4-cyanophenyl)-5-methyl-1H-pyrrol-1-yl]methyl}pyridine-3-carboxylate
• CAS NO: 894075-22-0
• Molecular Weight: 404.856
• Mol File: 894075-22-0.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-chloro-5-{[3-cyano-4-(4-cyanophenyl)-5-methyl-1H-pyrrol-1-yl]methyl}pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-chloro-5-{[3-cyano-4-(4-cyanophenyl)-5-methyl-1H-pyrrol-1-yl]methyl}pyridine-3-carboxylate(894075-22-0)
• EPA Substance Registry System: ethyl 2-chloro-5-{[3-cyano-4-(4-cyanophenyl)-5-methyl-1H-pyrrol-1-yl]methyl}pyridine-3-carboxylate(894075-22-0)

Safety Data

• Hazardous Substances Data: 894075-22-0(Hazardous Substances Data)

Upstream product

• 27519-25-1 trans-3-(4-cyanophenyl)acrylonitrile 
• 144918-37-6 (E)-ethyl 2-cyano-3-ethoxyacrylate 
• 894074-85-2 ethyl 2-chloro-5-methylpyridine-3-carboxylate 
• 894074-87-4 ethyl 5-(bromomethyl)-2-chloropyridine-3-carboxylate 
• 894074-92-1 4-(4-cyanophenyl)-5-methyl-1H-pyrrole-3-carbonitrile 

Downstream Products

• 894075-44-6 ethyl 2-chloro-5-({3-cyano-4-(4-cyanophenyl)-2-[(dimethylamino)methyl]-5-methyl-1H-pyrrol-1-yl}methyl)nicotinate 

Relevant articles and documents

Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists

A series of 4-phenylpyrrole derivatives D were designed, synthesized, and evaluated for their potential as novel orally available androgen receptor antagonists therapeutically effective against castration-resistant prostate cancers. 4-Phenylpyrrole compou

SUBSTITUTED PYRROLE DERIVATIVE

The present invention provides a novel pyrrole derivative having excellent androgen receptor antagonism, which is represented by the formula (I): wherein R1represents a hydrogen atom, a cyano group or a group represented by the formula COORA (wherein RA represents an optional substituted C1-6 alkyl group), R2 and R4 are the same or different, and each represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a trifluoromethyl group, an amino-C1-6 alkyl group, a mono-or di-substituted amino-C1-6 alkyl group, an optionally halogenated C1-6 alkyl group substituted with an optionally substituted hydroxyl group, a C2-6 alkenyl group substituted with an optionally substituted hydroxyl group, a C1-6 alkyl group substituted with an optionally substituted and optionally oxidized thiol group, an optionally substituted with and optionally oxidized thiol group, a cyano group, an acyl group, an optionally substituted oxazolyl group or a 1,3-dioxolan-2-yl group, R3 represents a group represented by the formula (a): (wherein X represents a halogen atom, Y represents a carbon atom or a nitrogen atom, Alk represents an optionally substituted C 1-4 alkylene group, and RB represents a hydrogen atom or an acyl group), and R5 represents a phenyl group which has a cyano group at a 4-position or a 3-position thereof, and may be further substituted, or a salt thereof. The present invention also provides an androgen receptor antagonist containing the pyrrole derivative, or a salt thereof.