894147-75-2Relevant academic research and scientific papers
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine
Deng, Hongfeng,Bannister, Thomas D.,Jin, Lei,Babine, Robert E.,Quinn, Jesse,Nagafuji, Pamela,Celatka, Cassandra A.,Lin, Jian,Lazarova, Tsvetelina I.,Rynkiewicz, Michael J.,Bibbins, Frank,Pandey, Pramod,Gorga, Joan,Meyers, Harold V.,Abdel-Meguid, Sherin S.,Strickler, James E.
, p. 3049 - 3054 (2008/09/21)
Using an α-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.
