89424-76-0Relevant academic research and scientific papers
Asymmetric routes in the reaction of cyclic ketene ortho ester with aldehydes involving the use of chiral Lewis acid
Yu,Lee,Chun,Choi,Kang
, p. 2698 - 2699 (2001)
Enantio- and diastereoselective synthesis of threo 2 and erythro 3 was accomplished by the conversion of 1 with aldehydes promoted by chiral borane 10; enantioselctivities range from 45-95% ee, while diastereoselectivities vary from 4.3-49:1 with 8 differ
1,3-Dioxan-5-ylalkenoic acids
-
, (2008/06/13)
The invention concerns novel 4-phenyl-1,3-dioxan-5-ylalkenoic acid derivatives of the formula I having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or arylalkyl, Rc is hydroxy, alkoxy or alkanesulphonamido, n is 1 or 2, A is ethylene or vinylene, Y is (2-5C)polymethylene optionally substituted by alkyl, and benzene ring B is optionally substituted phenyl, or, when Rc is hydroxy, a salt thereof. The acid derivatives antagonize one or more of the actions of thromboxane A2 (TXA2) and are expected to be of value in those disease conditions in which TXA2 is involved. The invention also provides pharmaceutical compositions containing an acid derivative of formula I, and processes for their chemical production.
