89434-30-0Relevant academic research and scientific papers
(METH) ACRYLATE AND METHOD FOR PRODUCING THE SAME, AND (CO) POLYMER THEREOF
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Paragraph 0066; 0090, (2018/03/23)
PROBLEM TO BE SOLVED: To provide a novel (meth) acrylate for dilution having a low viscosity and a high refractive index, a homopolymer of which has high heat resistance. SOLUTION: The present invention relates to a (meth) acrylate represented by the following formula (1), a homopolymer of the (meth) acrylate or a copolymer of the (meth) acrylate and another monomer (in the formula, R1 is an alkyl group having carbon atoms of one or more and four or less, and R2 is a hydrogen atom or a methyl group). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents
Cloonan, Suzanne M.,Keating, John J.,Butler, Stephen G.,Knox, Andrew J.S.,Jorgensen, Anne M.,Peters, Guenther H.,Rai, Dilip,Corrigan, Desmond,Lloyd, David G.,Williams, D. Clive,Meegan, Mary J.
experimental part, p. 4862 - 4888 (2010/01/16)
The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4-MTA analogues were synthesised with or without N-alkyl and/or C-α methyl or ethyl groups so that their potential SERT-dependent antiproliferative activity could be assessed. Many of the compounds displayed SERT-binding activity as well as cytotoxic activity. While there was no direct correlation between these two effects, a number of derivatives displayed anti-tumour effects in lymphoma, leukaemia and breast cancer cell lines, showing further potential to be developed as possible chemotherapeutic agents.
