894351-84-9 Usage
Uses
Used in Pharmaceutical Industry:
(1E)-N-Methyl-2-[1-(phenylmethyl)-1H-indol-5-yl]ethenesulfonamide is used as a key intermediate in the preparation of Naratriptan, a medication used for the acute treatment of migraine headaches. It is also utilized in the synthesis of other indole sulfonamide derivatives, which have potential applications in various therapeutic areas, such as cardiovascular, neurological, and oncological treatments.
Used in Chemical Research:
As a white solid with distinct chemical properties, (1E)-N-Methyl-2-[1-(phenylmethyl)-1H-indol-5-yl]ethenesulfonamide can be employed in chemical research for the development of new synthetic routes, optimization of existing methods, and exploration of novel applications in various fields, including materials science, agrochemistry, and environmental chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 894351-84-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,4,3,5 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 894351-84:
(8*8)+(7*9)+(6*4)+(5*3)+(4*5)+(3*1)+(2*8)+(1*4)=209
209 % 10 = 9
So 894351-84-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2O2S/c1-19-23(21,22)12-10-15-7-8-18-17(13-15)9-11-20(18)14-16-5-3-2-4-6-16/h2-13,19H,14H2,1H3/b12-10+
894351-84-9Relevant academic research and scientific papers
New synthesis of naratriptan
Poszavacz, Laszlo,Simig, Gyula,Fetter, Jozsef,Bertha, Ferenc
, p. 713 - 719 (2007/10/03)
A new synthesis of N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide (naratriptan, 1a) has been elaborated starting from 1-benzyl-1H-indole-5-carbaldehyde (14b). The 1-benzyl group proved to be an advantageous protecting group in the course of the construction of the ethanesulfonamide and methylpipieridinyl side-chains and it was removed in the last step of the synthesis.{A figure is presented}.
