89455-99-2

Upstream product

• 89455-94-7 Acetic acid (2-methyl-[1,3]dithian-2-yl)-(3,4,5-trimethoxy-phenyl)-methyl ester 
• 89455-97-0 4-Methyl-2-oxo-5-(3,4,5-trimethoxy-phenyl)-2,5-dihydro-furan-3-carboxylic acid methyl ester 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 89455-95-8 1-acetoxy-1-(3,4,5-trimethoxyphenyl)propanone 
• 89455-98-1 (4S,5R)-4-Methyl-2-oxo-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-3-carboxylic acid methyl ester 
• 141069-51-4 (3R,4S)-3-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-4-(3,4,5-trimethoxy-phenyl)-butyric acid 
• 89455-93-6 2-methyl-2-(3,4,5-trimethoxyphenylhydroxymethyl)-1,3-dithiane 

Relevant academic research and scientific papers

A novel stereoselective route to γ-butyrolactones

Treatment of the products obtained from conjugate additions of sulfoxides to α,β-unsaturated carbonyl compounds with soft electrophiles resulted in intramolecular displacement of the sulfinyl group by the carbonyl to give γ-butyrolactones. This novel cyclisation works best for benzylic sulfoxides and provides a concise route to trans-β,γ-disubstituted lactones with high stereoselectivity.

THE TOTAL SYNTHESIS OF (+/-)-MEGAPHONE, A CYTOTOXIC NEOLIGNAN

The racemic megaphone, a cytotoxic neolignan, has been synthesized from 3,4,5-trimethoxybenzaldehyde via an intermediate, 2-methoxycarbonyl-3-methyl-4-(3,4,5-trimethoxyphenyl)-γ-butyrolactone.