89463-74-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridazinecarboxylic acid, hydrazide (7CI) is used as a building block for the synthesis of various pharmaceuticals due to its potential biological activities, such as antitumor, antiviral, and antifungal properties. Its incorporation into drug molecules can enhance their therapeutic effects and target specific diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyridazinecarboxylic acid, hydrazide (7CI) serves as a key component in the development of new agrochemicals, contributing to the creation of effective pesticides and other agricultural products.
Used in Industrial Applications:
3-Pyridazinecarboxylic acid, hydrazide (7CI) is used as a corrosion inhibitor in industrial settings, helping to protect materials from degradation and extending their lifespan. Its ability to chelate metal ions also makes it a valuable compound in various industrial processes.

Upstream product

• 1126-10-9 ethyl 3-pyridazinecarboxylate 
• 2164-61-6 pyridazine-3-carboxylic acid 
• 1632-76-4 3-methylpyridazine 
• 34253-02-6 Methyl pyridazine-3-carboxylate 

Relevant academic research and scientific papers

Non-Porous Iron(II)-Based Sensor: Crystallographic Insights into a Cycle of Colorful Guest-Induced Topotactic Transformations

Materials capable of sensing volatile guests at room temperature by an easily monitored set of outputs are of great appeal for development as chemical sensors of small volatile organics and toxic gases. Herein the dinuclear iron(II) complex, [FeII2(L)2(CH3CN)4](BF4)4?2 CH3CN (1) [L=4-(4-methylphenyl)-3-(3-pyridazinyl)-5-pyridyl-4H-1,2,4-triazole], is shown to undergo reversible single-crystal-to-single-crystal (SCSC) transformations upon exposure to vapors of different guests: 1 (MeCN)?2 (EtOH)→3 (H2O)?1 (MeCN). Whilst 1 and 2 remain dimetallic, SCSC to 3 involves conversion to a 1D polymeric chain (due to a change in L bridging mode), which, remarkably, can undergo SCSC de-polymerization, reforming dimetallic 1. Additionally, SC-XRD studies of two ordered transient forms, 1TF3 and 2TF3, confirm that guest exchange occurs by diffusion of the new guests into the non-porous lattices as the old guests leave. These reversible SCSC events also induce color and magnetic responses. Indeed dark red 1 is spin crossover active (T1/2↓ 356 K; T1/2↑ 369 K), whilst orange 2 and yellow 3 remain high spin.

HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

P2X7 MODULATORS

The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.