89478-03-5

Upstream product

• 106-45-6 para-thiocresol 
• 130-15-4 [1,4]naphthoquinone 
• 145146-93-6 1,4-Dimethoxy-2-<(4-methylphenyl)thio>naphthalene 
• 103-19-5 di(p-tolyl) disulfide 
• 10075-62-4 1,4-dimethoxynaphthalene 
• 26473-08-5 [²H₆]-1,4-naphthoquinone 
• 39549-10-5 1-[(4-methylphenyl)sulfanyl]pyrrolidine-2,5-dione 

Downstream Products

• 89478-07-9 2-bromo-3-p-tolylsulfanyl-[1,4]naphthoquinone 
• 114740-45-3 bis-2-(4-phenyl)-3-(4-bromophenyl)sulphanyl-1,4-naphthalenedione 
• 1146805-84-6 2-(4-methylphenyl)-3-(4-methoxyphenyl)sulphanyl-1,4-naphthalenediol 
• 1146805-85-7 2-(4-methylphenyl)-3-(4-bromophenyl)sulphanyl-1,4-naphthalenediol 
• 1099739-80-6 2,3-di-(4-methylphenyl)sulphanyl-1,4-naphthalenediol 
• 1025772-46-6 C₁₇H₁₄O₂S 

Relevant academic research and scientific papers

Synthetic method for quinone aryl thioether compounds

The invention relates to a synthetic method for quinone aryl thioether compounds represented by a formula (III). The method comprises the following steps: in an organic solvent, in the presence of a catalyst, an oxidizing agent, an organic ligand and an accelerant, performing a reaction on a compound represented by a formula (I) and a compound represented by a formula (II) for 6-10 hours at 50-70 DEG C; after reaction, performing post-treatment to obtain the compound represented by a formula (III) as shown in the description, wherein R is selected from H, C1-C6 alkyl, C1-C6 alkoxyl, halogen or nitryl. Through comprehensive screening and synergistic effect of the catalyst, the oxidizing agent, the organic ligand, the accelerant and the organic solvent, the method can obtain the targeted product at a high yield. The invention provides a brand-new synthetic method for the compounds and has good application values and industrial production potentials.

Silver-Catalyzed Direct Thiolation of Quinones by Activation of Aryl Disulfides to Synthesize Quinonyl Aryl Thioethers

A silver-catalyzed coupling reaction of quinones with aryl disulfides for the synthesis of quinonyl aryl thioethers is described. In the presence of AgOAc (0.2 equiv)/dppp (0.24 equiv) as the catalyst, (NH4)2S2O8/sub

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10-20 nM reversible inhibitors of the Escherichia coli FabH enzyme. The inhibitors were also effective but to a lesser degree (30 nM-5 μM), against the Mycobacter

Synthesis of benzo[b]naphtho[2,3-d]thiophene-6,11-diones via palladium(II) acetate-mediated cyclization of 3-arylthio-1,4-naphthoquinone

Palladium(II)-mediated oxidative cyclization of 3-arylthio-1,4- naphthoquinone (4) giving biologically important benzo[b]naphtho-[2,3-d] thiophene-6,11-diones (2) has been performed with a stoichiometric amount of palladium(II) acetate in distillated acet

Asymmetric Diels-Alder Reactions of (S)-2-(p-Tolylsulfinyl)-1,4-naphthoquinones

The asymmetric Diels-Alder reactions of (S)-2-(p-tolylsulfinyl)-1,4-naphthoquinones 1a-c with cyclic dienes have been explored.The high ? facial diastereoselectivity observed can be reversed in the presence of ZnBr2.Evidence is presented to show that the regiochemical outcome of these reactions is controlled only by the sulfinyl group.The in situ cycloaddition/pyrolytic sulfoxide elimination starting from chiral 1a-c offers a convenient new route for the construction of enantiomerically pure 1,4-dihydro-9,10-anthraquinones (+)-10 and (+)-12a-c.